IL24
Function
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
Post-translational modifications
Glycosylated.
Ubiquitination at Lys-122 promotes proteasomal degradation.
Sequence Similarities
Belongs to the IL-10 family.
Tissue Specificity
Up-regulated in melanoma cells induced to terminally differentiate.
Cellular localization
- Secreted
Alternative names
MDA7, ST16, IL24, Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, Suppression of tumorigenicity 16 protein, MDA-7