IL26

Function

May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

Sequence Similarities

Belongs to the IL-10 family.

Tissue Specificity

Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).

Cellular localization

• Secreted

Alternative names

AK155, IL26, Interleukin-26, IL-26, Protein AK155

Database links

swissprot:Q9NPH9 omim:605679 entrezGene:55801

Other research areas

• Immuno-oncology