IL2RA
GeneName
IL2RA
Summary
IL2RA, also known as CD25 or p55, is a 31 kDa glycoprotein that is primarily expressed on the surface of activated T cells, regulatory T cells, and some other immune cells. It is a component of the interleukin-2 receptor complex, playing a crucial role in the binding of interleukin-2 (IL-2), which is essential for T cell proliferation and differentiation. IL2RA is localised to the external side of the plasma membrane and is involved in various immune response pathways, including the regulation of T cell activation and tolerance. Its function is critical for maintaining immune homeostasis and modulating inflammatory responses.
Importance
IL2RA is relevant to: - T cell biology, particularly in the context of immune responses and tolerance mechanisms - Autoimmune diseases, where dysregulation of IL2RA can lead to inappropriate T cell activation - Cancer immunotherapy, as it can influence the efficacy of therapies targeting the IL-2 pathway - Transplantation, where it plays a role in the regulation of graft-versus-host disease and transplant acceptance
Top Products
For researchers investigating IL2RA, we highly recommend the top-selling recombinant antibody, Anti-IL-2 Receptor alpha antibody [EPR6452] (ab128955). This antibody has been validated for use in immunohistochemistry (IHC) and immunocytochemistry (ICC), making it an excellent choice for various applications in your research. With 17 citations, it demonstrates a solid reputation within the scientific community, reflecting its reliability and effectiveness in detecting IL2RA. The recombinant nature of this antibody ensures batch-to-batch consistency, providing you with confidence in your experimental results. The PE/Cy7® Anti-IL-2 Receptor alpha antibody [MEM-181] (ab234252) is an excellent option for researchers looking to study IL2RA in their experiments.
Abcam Product Citation Summary
The data indicates that the IL2RA antibody (ab46036) has been utilised in studies focusing on human peripheral blood mononuclear cells (PBMCs) and human haematopoietic progenitor cells (HPCs). The research appears to explore the immunomodulatory effects of specific treatments, highlighting the relevance of IL2RA in immune response studies.
Abcam Product Citation Table
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Involvement in disease
Type 1 diabetes mellitus 10
T1D10
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Immunodeficiency 41 with lymphoproliferation and autoimmunity
IMD41
A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
None
The disease is caused by variants affecting the gene represented in this entry.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD25, Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, IL2RA
Database links
swissprot:P01589 entrezGene:3559 entrezGene:443435 entrezGene:920 swissprot:P01730 omim:147730
Other research areas
- Immuno-oncology
- Neuroscience