Il2rb

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Cell surface

Alternative names

CD122, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, Il2rb

Database links

swissprot:P16297 entrezGene:16185

Other research areas

• Immuno-oncology