Skip to main content

IL-34

Function

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).

Sequence similarities

Belongs to the IL-34 family.

Cellular localization

  • Secreted

Alternative names

  • Interleukin-34
  • IL-34
  • Il34

Target type

Proteins

Molecular weight

26764Da