Il4r

Domain

The extracellular domain represents the IL4 binding protein (IL4BP).

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

Post-translational modifications

On IL4 binding, phosphorylated on C-terminal tyrosine residues.

Soluble IL4R can also be produced by proteolytic cleavage at the cell surface (shedding).

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Tissue Specificity

Expressed in both Th1 and Th2 cells.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Secreted

Alternative names

CD124, Il4ra, Il4r, Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA

Database links

swissprot:P16382 entrezGene:16190

Other research areas

• Immuno-oncology