IL-5RA

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Function

This is the receptor for interleukin-5. The alpha chain binds to IL5.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Tissue specificity

Expressed on eosinophils and basophils.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

• Interleukin-5 receptor subunit alpha
• IL-5 receptor subunit alpha
• IL-5R subunit alpha
• IL-5R-alpha
• IL-5RA
• CDw125
• IL5R
• IL5RA

Database links

• entrezGene:3568
• omim:147851
• swissprot:Q01344

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

47685Da