Il5ra
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Function
Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:1873482). Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
Tissue Specificity
Expressed on eosinophils and basophils. Also on B-cells.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD125, Il5r, Il5ra, Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA