Il7r
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Function
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Post-translational modifications
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Tissue Specificity
Spleen, thymus and fetal liver.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD127, Interleukin-7 receptor subunit alpha, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, Il7r