ILVBL
Function
Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway.
Sequence Similarities
Belongs to the TPP enzyme family.
Tissue Specificity
Expressed in all tissues tested, with highest expression in heart, pancreas and placenta.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass membrane protein
Alternative names
AHAS, HACL2, ILVBL, 2-hydroxyacyl-CoA lyase 2, Acetolactate synthase-like protein, IlvB-like protein