Inosine-5'-monophosphate dehydrogenase 2

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors.

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Ubiquitinated leading to its degradation by the proteasome.

The N-terminus is blocked.

Acetylated by CLOCK in a circadian manner (PubMed:28985504).

Belongs to the IMPDH/GMPR family.

IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor.

• Cytoplasm
• Nucleus
• Cytoplasm
• Cytosol
• Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion.

IMPD2, IMPDH2, Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2, IMPD 2, IMPDH 2, Inosine-5'-monophosphate dehydrogenase type II, IMP dehydrogenase II, IMPDH-II

• entrezGene:3615
• omim:146691
• swissprot:P12268

Proteins

Metabolism

55805Da