INA
Developmental stage
Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.
Function
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity).
Post-translational modifications
O-glycosylated.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Found predominantly in adult CNS.
Alternative names
NEF5, INA, Alpha-internexin, Alpha-Inx, 66 kDa neurofilament protein, Neurofilament 5, NF-66, Neurofilament-66