ING5
Domain
The PHD-type zinc finger mediates the binding to H3K4me3.
Function
Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).
Sequence Similarities
Belongs to the ING family.
Tissue Specificity
Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.
Cellular localization
- Nucleus
- Chromosome
- Localizes to transcription start sites.
Alternative names
Inhibitor of growth protein 5, p28ING5, ING5