Inhbe
Developmental stage
First expression in embryonic liver is detected at 17.5 dpc.
Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Sequence Similarities
Belongs to the TGF-beta family.
Cellular localization
- Secreted
Alternative names
Inhibin beta E chain, Activin beta-E chain