INO80

Domain

The DBINO region is involved in binding to DNA.

Function

ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Tissue specificity

According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.

Cellular localization

• Cytoplasm
• Nucleus
• Cytoplasm
• Cytoskeleton
• Spindle
• Chromosome
• Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067).

Alternative names

• Chromatin-remodeling ATPase INO80
• hINO80
• DNA helicase-related INO80 complex homolog 1
• DNA helicase-related protein INO80
• INO80 complex subunit A
• INO80
• INO80A
• INOC1
• KIAA1259

Database links

• entrezGene:54617
• omim:610169
• swissprot:Q9ULG1

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

176753Da