INPP4B
Function
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).
Pathway
Signal transduction; phosphatidylinositol signaling pathway.
Sequence Similarities
Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
Tissue Specificity
Widely expressed with highest levels occurring in the skeletal muscle and heart.
Alternative names
Inositol polyphosphate 4-phosphatase type II, INPP4B