INPP4B

Function

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).

Pathway

Signal transduction; phosphatidylinositol signaling pathway.

Sequence similarities

Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

Tissue specificity

Widely expressed with highest levels occurring in the skeletal muscle and heart.

Alternative names

• Inositol polyphosphate 4-phosphatase type II
• INPP4B

Database links

• entrezGene:8821
• omim:607494
• swissprot:O15327

Target type

Proteins

Molecular weight

104738Da