INSL3
Function
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Involvement in disease
Cryptorchidism
CRYPTO
One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the insulin family.
Tissue Specificity
Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.
Cellular localization
- Secreted
Alternative names
RLF, RLNL, INSL3, Insulin-like 3, Leydig insulin-like peptide, Relaxin-like factor, Ley-I-L