INSRR
Domain
The extracellular domain is required for sensing alterations in external pH.
Function
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Post-translational modifications
Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
IRR, INSRR, Insulin receptor-related protein, IR-related receptor