Integrin beta-4

The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.

The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.

Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.

Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins (By similarity).

Belongs to the integrin beta chain family.

• Cell membrane
• Single-pass type I membrane protein
• Cell membrane
• Lipid-anchor
• Cell junction
• Hemidesmosome
• Colocalizes with DST at the leading edge of migrating keratinocytes.

CD104, Integrin beta-4, Itgb4

• entrezGene:192897
• swissprot:A2A863

Proteins

Oncology

201650Da