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Integrin beta-5

Domain

The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.

Function

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.

Sequence similarities

Belongs to the integrin beta chain family.

Cellular localization

  • Cell membrane
  • Single-pass type I membrane protein

Alternative names

  • Integrin beta-5
  • ITGB5

Target type

Proteins

Primary research area

Oncology

Molecular weight

88054Da