Inter-alpha-trypsin inhibitor heavy chain H3
Function
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Post-translational modifications
Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
Sequence Similarities
Belongs to the ITIH family.
Cellular localization
- Secreted
Alternative names
Inter-alpha-trypsin inhibitor heavy chain H3, ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3, Serum-derived hyaluronan-associated protein, SHAP, ITIH3