Interferon-activable protein 204

Domain

The 2 HIN-200 domains are able to interact with RUNX2.

Function

Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity (PubMed:16244109, PubMed:25710914, PubMed:30936875). Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway (PubMed:25710914, PubMed:33619523). Mechanistically, gets acetylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release (PubMed:28529930). Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.

Post-translational modifications

Acetylated upon bacterial infection, leading to translocation from nucleus to cytoplasm and subsequent recruitment of STING to activate IFN-beta production.

Sequence Similarities

Belongs to the HIN-200 family.

Tissue Specificity

Present in osteoblasts (at protein level).

Cellular localization

• Nucleus
• Nucleus
• Nucleolus
• Cytoplasm
• Nuclear in proliferating cells, translocates to cytosol during cell differentiation or bacterial infection.

Alternative names

Interferon-activable protein 204, Ifi-204, Interferon-inducible protein p204, Ifi204

Database links

swissprot:P0DOV2 swissprot:脗聽P0DOV1 entrezGene:381308 entrezGene:15951 swissprot:P15092 swissprot:Q08619