Skip to main content

INTS11

OverviewProducts

Domain

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.

Function

Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.

Cellular localization

  • Nucleus
  • Cytoplasm

Alternative names

  • Integrator complex subunit 11
  • Int11
  • Cleavage and polyadenylation-specific factor 3-like protein
  • Protein related to CPSF subunits of 68 kDa
  • CPSF3-like protein
  • RC-68
  • CPSF3L
  • RC68
  • INTS11

Database links

Target type

Proteins

Molecular weight

67663Da