INTS5
Function
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
Sequence Similarities
Belongs to the Integrator subunit 5 family.
Cellular localization
- Nucleus membrane
- Multi-pass membrane protein
- Nucleus
- Cytoplasm
Alternative names
KIAA1698, INTS5, Integrator complex subunit 5, Int5