IPPK
Domain
The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Function
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
Sequence Similarities
Belongs to the IPK1 type 2 family.
Tissue Specificity
Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
C9orf12, IPPK, Inositol-pentakisphosphate 2-kinase, IPK1 homolog, InsP5 2-kinase