IQCG
Domain
The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low.
Function
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.
Sequence Similarities
Belongs to the DRC9 family.
Cellular localization
- Cytoplasm
- Cell projection
- Cilium
- Flagellum
- Cell projection
- Cilium
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cytoskeleton
- Flagellum axoneme
- First detected in the cytoplasm of pachytene spermatocytes. Colocalizes with alpha-tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct.
Alternative names
DRC9, IQCG, Dynein regulatory complex protein 9, IQ domain-containing protein G