IRAG2
Function
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity).
Post-translational modifications
The removal of the C-terminal lumenal domain occurs by proteolytic processing.
Sequence Similarities
Belongs to the IRAG2 family.
Tissue Specificity
Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles.
Cellular localization
- Processed inositol 1,4,5-triphosphate receptor associated 2
- Cytoplasm
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Nucleus envelope
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Spindle pole
- Chromosome
- Colocalized with ITPR3 on the endoplasmic reticulum membrane.
Alternative names
JAW1, LRMP, IRAG2, Lymphoid-restricted membrane protein, Protein Jaw1