IRAK2
Domain
The protein kinase domain is predicted to be catalytically inactive.
Function
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Tissue Specificity
Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
Alternative names
Interleukin-1 receptor-associated kinase-like 2, IRAK-2, IRAK2