IST1
Function
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
Sequence Similarities
Belongs to the IST1 family.
Cellular localization
- Cytoplasmic vesicle
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Midbody
- Nucleus envelope
- Localizes to centrosome and midbody of dividing cells (PubMed:19129479, PubMed:19129480, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase.
Alternative names
KIAA0174, IST1, IST1 homolog, hIST1, Charged multivesicular body protein 8, Putative MAPK-activating protein PM28, CHMP8