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ITGA2

OverviewProducts

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A.

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.

Sequence similarities

Belongs to the integrin alpha chain family.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

  • Integrin alpha-2
  • CD49 antigen-like family member B
  • Collagen receptor
  • Platelet membrane glycoprotein Ia
  • VLA-2 subunit alpha
  • GPIa
  • ITGA2
  • CD49B

Database links

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology

Molecular weight

129295Da