Itga2

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.

Sequence Similarities

Belongs to the integrin alpha chain family.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD49b, Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, VLA-2 subunit alpha, GPIa, Itga2

Database links

swissprot:Q62469 entrezGene:16398

Other research areas

• Immuno-oncology