Itga2b
Function
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Post-translational modifications
Integrin alpha-IIb heavy chain
Cleaved by ELANE; the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3.
Sequence Similarities
Belongs to the integrin alpha chain family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD41, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, GPIIb, Itga2b