Itgad

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Belongs to the integrin alpha chain family.

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

• Membrane
• Single-pass type I membrane protein

CD11d, Integrin alpha-D, ADB2, CD11 antigen-like family member D, Leukointegrin alpha D, ITGAD

• entrezGene:3681
• omim:602453
• swissprot:Q13349

Proteins

Immunology & Infectious Disease

126758Da