ITGAD
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Function
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.
Sequence Similarities
Belongs to the integrin alpha chain family.
Tissue Specificity
Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD11d, Integrin alpha-D, ADB2, CD11 antigen-like family member D, Leukointegrin alpha D, ITGAD