Itgae

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.

Sequence Similarities

Belongs to the integrin alpha chain family.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD103, Integrin alpha-E, Integrin alpha M290, Itgae

Database links

swissprot:Q60677 entrezGene:16407

Other research areas

• Immuno-oncology