ITGAE

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Sequence similarities

Belongs to the integrin alpha chain family.

Tissue specificity

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

• Integrin alpha-E
• HML-1 antigen
• Integrin alpha-IEL
• Mucosal lymphocyte 1 antigen
• ITGAE

Database links

• entrezGene:3682
• omim:604682
• swissprot:P38570

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology

Molecular weight

130159Da