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Itgam

OverviewProducts

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038).

Sequence similarities

Belongs to the integrin alpha chain family.

Tissue specificity

Predominantly expressed in monocytes and granulocytes (PubMed:3887182, PubMed:8986723). Expressed in a subset of peritoneal mast cells (PubMed:9862668). Expressed in microglia (at protein level) (PubMed:18685038).

Cellular localization

  • Cell membrane
  • Single-pass type I membrane protein
  • Membrane raft
  • Single-pass type I membrane protein

Alternative names

  • Integrin alpha-M
  • CD11 antigen-like family member B
  • CR-3 alpha chain
  • Cell surface glycoprotein MAC-1 subunit alpha
  • Leukocyte adhesion receptor MO1
  • Itgam

Database links

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology
  • Neuroscience

Molecular weight

127481Da