Itgax

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).

Sequence Similarities

Belongs to the integrin alpha chain family.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax

Database links

swissprot:Q9QXH4 entrezGene:16411

Other research areas

• Immuno-oncology