ITGAX

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).

Sequence similarities

Belongs to the integrin alpha chain family.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

• Integrin alpha-X
• CD11 antigen-like family member C
• Itgax

Database links

• entrezGene:16411
• swissprot:Q9QXH4

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology

Molecular weight

129151Da