ITGAX

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Belongs to the integrin alpha chain family.

Predominantly expressed in monocytes and granulocytes.

• Membrane
• Single-pass type I membrane protein

CD11c, CD11C, ITGAX, Integrin alpha-X, CD11 antigen-like family member C, Leu M5

• entrezGene:3687
• omim:151510
• swissprot:P20702

Proteins

Immunology & Infectious Disease

• Immuno-oncology

127829Da