ITGAX
GeneName
ITGAX
Summary
ITGAX, also known as CD11c or integrin alpha X, is a 128 kDa transmembrane protein predominantly expressed on dendritic cells, macrophages, and some activated T cells. It is a member of the integrin family and forms a complex with integrin beta 2, localising to the cell surface and plasma membrane. ITGAX plays a crucial role in various biological processes including cell adhesion, cell-matrix interactions, and integrin-mediated signalling. It is involved in the defence response to viral infections and positively regulates angiogenesis, cell migration, and myelination, highlighting its importance in immune responses and tissue remodelling.
Importance
ITGAX is relevant to: - Immune responses, particularly in the activation and migration of dendritic cells and macrophages during pathogen recognition - Angiogenesis and tissue repair processes due to its role in cell adhesion and signalling - The regulation of myelination, which is essential for proper nervous system function - Potential therapeutic targets in cancer immunotherapy and autoimmune diseases, given its involvement in immune cell interactions and migration
Top Products
For researchers investigating ITGAX, we highly recommend the top-selling recombinant antibody, Anti-CD11c antibody [EP1347Y] (ab52632). This well-cited antibody has garnered 158 citations, reflecting its strong reputation in the field. It has been validated for use in various applications, including immunohistochemistry (IHC), western blotting (WB), and immunoprecipitation (IP), making it a versatile choice for your research needs. The recombinant nature of this antibody ensures batch-to-batch consistency, providing reliable results in your experiments.
Abcam Product Citation Summary
The data indicates that ITGAX is being studied in various contexts, particularly in relation to immune cell characterization and cancer. The use of Abcam antibodies in both mouse and human tissues highlights the relevance of ITGAX in glioblastoma, dendritic cell characterization, and immune cell infiltration in different diseases, including IgG4-related disease and head and neck squamous cell carcinoma.
Abcam Product Citation Table
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Function
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Sequence Similarities
Belongs to the integrin alpha chain family.
Tissue Specificity
Predominantly expressed in monocytes and granulocytes.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD11c, CD11C, ITGAX, Integrin alpha-X, CD11 antigen-like family member C, Leu M5
Database links
swissprot:P20702 omim:151510 entrezGene:3687
Other research areas
- Immuno-oncology