IVL
Function
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Post-translational modifications
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
Sequence Similarities
Belongs to the involucrin family.
Tissue Specificity
Keratinocytes of epidermis and other stratified squamous epithelia.
Cellular localization
- Cytoplasm
- Constituent of the scaffolding of the cornified envelope.
Alternative names
Involucrin, IVL