JADE1
Domain
The 2 PHD-type zinc fingers are required for transcriptional activity.
Function
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).
Sequence Similarities
Belongs to the JADE family.
Tissue Specificity
Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
Cellular localization
- Nucleus
- Chromosome
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Cilium basal body
- Localizes to the ciliary transition zone.
Alternative names
KIAA1807, PHF17, JADE1, Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17