JAKMIP1
Function
Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Sequence Similarities
Belongs to the JAKMIP family.
Tissue Specificity
Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Membrane
- Peripheral membrane protein
- Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
Alternative names
GABABRBP, JAMIP1, MARLIN1, JAKMIP1, Janus kinase and microtubule-interacting protein 1, GABA-B receptor-binding protein, Multiple alpha-helices and RNA-linker protein 1, Marlin-1