JAML

Domain

The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).

Function

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Tissue specificity

Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Cell junction
• Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

Alternative names

• Junctional adhesion molecule-like
• Adhesion molecule interacting with CXADR antigen 1
• Dendritic cell-specific protein CREA7-1
• JAML
• AMICA1
• UNQ722/PRO1387

Database links

• entrezGene:120425
• omim:609770
• swissprot:Q86YT9

Target type

Proteins

Molecular weight

44339Da