JPT1
Function
Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APCGSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408).
Sequence Similarities
Belongs to the JUPITER family.
Tissue Specificity
Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
ARM2, HN1, JPT1, Jupiter microtubule associated homolog 1, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein