JPT2

Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062).

(Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2.

Belongs to the JUPITER family.

Expressed in liver, kidney, prostate, testis and uterus.

• Cytoplasm
• Nucleus
• Colocalizes with type 1 ryanodine receptor (RYR1).

C16orf34, HN1L, L11, JPT2, Jupiter microtubule associated homolog 2, Hematological and neurological expressed 1-like protein, HN1-like protein

• entrezGene:90861
• swissprot:Q9H910

Proteins

20063Da