JTB
Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
Sequence Similarities
Belongs to the JTB family.
Tissue Specificity
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Mitochondrion
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Spindle
- Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Alternative names
HSPC222, JTB, Protein JTB, Jumping translocation breakpoint protein, Prostate androgen-regulated protein, PAR protein