KBTBD7
Domain
The ATG8 interaction motif (AIM) mediates interaction with proteins of the ATG8 family including GABARAP.
The BTB domain is required for interaction with CUL3.
The Kelch repeats mediate interaction with TIAM1, a CUL3(KBTBD6/7) E3 ubiquitin ligase substrate.
Function
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205).
Pathway
Protein modification; protein ubiquitination.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
Kelch repeat and BTB domain-containing protein 7, KBTBD7