KBTBD8
Developmental stage
Down-regulated in differentiating embryonic stem cells (ESCs) (at protein level).
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Sequence Similarities
Belongs to the KBTBD8 family.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Spindle
- Golgi apparatus
- Translocates to the spindle apparatus during mitosis.
Alternative names
KIAA1842, TAKRP, KBTBD8, Kelch repeat and BTB domain-containing protein 8, T-cell activation kelch repeat protein, TA-KRP