Kcnd3
Domain
Two N-terminal domains regulate binding to and modulation by KCNIP1.
Function
Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (By similarity). In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (By similarity).
Post-translational modifications
Regulated through phosphorylation at Ser-569 by CaMK2D.
Sequence Similarities
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell membrane
- Sarcolemma
- Multi-pass membrane protein
- Cell projection
- Dendrite
- Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression.
Alternative names
A-type voltage-gated potassium channel KCND3, Potassium voltage-gated channel subfamily D member 3, Voltage-gated potassium channel subunit Kv4.3, Kcnd3