KCNJ12

Domain

Phosphatidylinositol 4,5-bisphosphate binding to the cytoplasmic side of the channel triggers a conformation change leading to channel opening.

Function

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sequence Similarities

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.

Cellular localization

• Membrane
• Multi-pass membrane protein
• Cell membrane
• Multi-pass membrane protein

Alternative names

IRK2, KCNJN1, KCNJ12, ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir2.2, Inward rectifier K(+) channel Kir2.2v, IRK-2

Database links

swissprot:Q14500 omim:602323 entrezGene:100290070 entrezGene:100131509 entrezGene:3768