KCTD12
Function
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Tissue Specificity
Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.
Cellular localization
- Presynaptic cell membrane
- Postsynaptic cell membrane
Alternative names
C13orf2, KIAA1778, PFET1, KCTD12, BTB/POZ domain-containing protein KCTD12, Pfetin, Predominantly fetal expressed T1 domain